Keywords
Cg1
deseperanza conductual
neuronas
zarzamora Anthocyanins
blackberry
Cg1
depression-like behavior
neurons
How to Cite
Abstract
Stress can predispose to the development of psychiatric disorders such as depression. Berry consumption has been associated with a lower risk of developing depression, due to its high content of polyphenols and anthocyanins. This study evaluated the effect of blackberry juice on depression-like behavior and the number of neurons in the Cg1 region of the prefrontal cortex of rats. Forty-four male Wistar rats were divided into five groups: vehicle, low and high blackberry, fluoxetine and diazepam. The effects were evaluated in the open field and forced swimming tests. The histological analysis was performed using the stain cresyl violet. Groups treated with the high dose of blackberry showed antidepressant-like effects, as well as a greater number of neurons in the Cg1 region. Results suggest that blackberry juice could prevent psychiatric disorders associated with stress.
References
Awasthi, S., Pan, H., LeDoux, J. E., Cloitre, M., Altemus, M., McEwen, B., Silbersweig, D., & Stern, E. (2020). The bed nucleus of the stria terminalis and functionally linked neurocircuitry modulate emotion processing and HPA axis dysfunction in posttraumatic stress disorder. NeuroImage: Clinical, 28, 102-442. https://doi.org/10.1016/j.nicl.2020.102442
Casadesus, G., Shukitt-Hale, B., Stellwagen, H. M., Zhu, X., Lee, H. G., Smith, M. A., & Joseph, J. A. (2004). Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutritional Neuroscience, 7(5–6), 309–316. https://doi.org/10.1080/10284150400020482
Chang, S. C., Cassidy, A., Willett, W. C., Rimm, E. B., O’Reilly, E. J. y Okereke, O. I. (2016). Dietary flavonoid intake and risk of incident depression in midlife and older women. American Journal of Clinical Nutrition, 104(3), 704–714. https://doi.org/10.3945/ajcn.115.124545
Contreras, C. M., Rodríguez-Landa, J. F., Gutiérrez-García, A. G., y Bernal-Morales, B. (2001). The lowest effective dose of fluoxetine in the forced swim test significantly affects the firing rate of lateral septal nucleus neurones in the rat. Journal of Psychopharmacology, 15(4), 231–236. https://doi.org/10.1177/026988110101500401
Contreras, C. M., Martínez-Mota, L., & Saavedra, M. (1998). Desipramine restricts estral cycle oscillations in swimming. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 22(7), 1121-1128.
Cryan, J. F., Page, M. E., y Lucki, I. (2005). Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacology, 182(3), 335–344. https://doi.org/10.1007/s00213-005-0093-5
Cryan, J. F., & Lucki, I. (2000). Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors. Journal of Pharmacology and Experimental Therapeutics, 295(3), 1120-1126.
De Kloet, E. R., & Molendijk, M. L. (2016). Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism. Neural Plasticity, 2016. https://doi.org/10.1155/2016/6503162
De Kloet, E. Ron, Joëls, M., & Holsboer, F. (2005). Stress and the brain: From adaptation to disease. Nature Reviews Neuroscience, 6(6), 463–475. https://doi.org/10.1038/nrn1683
Detke, M. J., Johnson, J., & Lucki, I. (1997). Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression. Experimental and Clinical Psychopharmacology, 5(2), 107–112. https://doi.org/10.1037/1064-1297.5.2.107
Detke, M. J., & Lucki, I. (1995). Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth. Behavioural Brain Research, 73(1–2), 43–46. https://doi.org/10.1016/0166-4328(96)00067-8
Dias, G. P., Cavegn, N., Nix, A., Do Nascimento Bevilaqua, M. C., Stangl, D., Zainuddin, M. S. A., Nardi, A. E., Gardino, P. F., y Thuret, S. (2012). The role of dietary polyphenols on adult hippocampal neurogenesis: Molecular mechanisms and behavioural effects on depression and anxiety. Oxidative Medicine and Cellular Longevity, 2012(s/n). https://doi.org/10.1155/2012/541971
Espejo, E. F., y Miñano, F. J. (1999). Prefrontocortical dopamine depletion induces antidepressant-like effects in rats and alters the profile of desipramine during Porsolt’s test. Neuroscience, 88(2), 609–615. https://doi.org/10.1016/S0306-4522(98)00258-9
Fang, J. L., Luo, Y., Jin, S. H., Yuan, K., & Guo, Y. (2020). Ameliorative effect of anthocyanin on depression mice by increasing monoamine neurotransmitter and up-regulating BDNF expression. Journal of Functional Foods, 66, 103757. https://doi.org/10.1016/J.JFF.2019.103757
Fernández-Demeneghi, R., Rodríguez-Landa, J. F., Guzmán-Gerónimo, R. I., Acosta-Mesa, H. G., Meza-Alvarado, E., Vargas-Moreno, I., & Herrera-Meza, S. (2019). Effect of blackberry juice (Rubus fruticosus L.) on anxiety-like behaviour in Wistar rats. International Journal of Food Sciences and Nutrition, 70(7), 856–867. https://doi.org/10.1080/09637486.2019.1580680
Fernández-Demeneghi, R. (2017). Evaluación del efecto del jugo de zarzamora (Rubus fruticosus) sobre la ansiedad experimental en la rata Wistar. Universidad Veracruzana. Instituto de Neuroetología. Xalapa. http://cdigital.uv.mx/handle/123456789/48374
Golovinskaia, O. y Wang, C.K. Review of Functional and Pharmacological Activities of Berries. Molecules 2021, 26, 3904. https://doi.org/10.3390/molecules26133904
Gutiérrez-García, A. G., Contreras, C. M., Mendoza-López, M. R., García-Barradas, O., y Cruz-Sánchez, J. S. (2007). Urine from stressed rats increases immobility in receptor rats forced to swim: Role of 2-heptanone. Physiology and Behavior, 91(1), 166–172. https://doi.org/10.1016/j.physbeh.2007.02.006
Hall, B. J., Pearson, L. S., y Buccafusco, J. J. (2010). Effect of the use-dependent, nicotinic receptor antagonist BTMPS in the forced swim test and elevated plus maze after cocaine discontinuation in rats. Neuroscience Letters, 474(2), 84–87.
https://doi.org/10.1016/j.neulet.2010.03.011
Hammen, C. (2005). Stress and depression. Annual Review of Clinical Psychology, 1, 293–319. https://doi.org/10.1146/annurev.clinpsy.1.102803.143938
Hemby, S. E., Lucki, I., Gatto, G., Singh, A., Thornley, C., Matasi, J., […] y Dworkin, S. I. (1997). Potential antidepressant effects of novel tropane compounds, selective for serotonin or dopamine transporters. Journal of Pharmacology and Experimental Therapeutics, 282(2), 727-733.
Huremović, D. (2019). Brief history of pandemics (pandemics throughout history). En Huremović, D. (eds) Psychiatry of Pandemics. Springer, Cham. https://doi.org/10.1007/978-3-030-15346-5_2
Imran, I., Javaid, S., Waheed, A., Rasool, M. F., Majeed, A., Samad, N., Saeed, H., Alqahtani, F., Ahmed, M. M., y Alaqil, F. A. (2021). Grewia asiatica Berry Juice Diminishes Anxiety, Depression, and Scopolamine-Induced Learning and Memory Impairment in Behavioral Experimental Animal Models. Frontiers in Nutrition, 7(January), 1–19. https://doi.org/10.3389/fnut.2020.587367
Jaffar-Medina, V., Rosado-Pérez, A. L., Flores-Serrano, A. G., Torres-Escalante, J. L., y Pineda, J. C. (2020). Los índices depresivos y antidepresivos durante la prueba de nado forzado se asocian diferencialmente con la estación del año y el ciclo estral en ratas Wistar hembras. Revista Biomédica, 31(2), 69-75.
Joëls, M., & Baram, T. Z. (2009). The neuro-symphony of stress. Nature reviews neuroscience, 10(6), 459-466.
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999). Causal relationship between stressful life events and the onset of major depression. American Journal of Psychiatry, 156(6), 837–841. https://doi.org/10.1176/ajp.156.6.837
Khalid, S., Barfoot, K. L., May, G., Lamport, D. J., Reynolds, S. A., y Williams, C. M. (2017). Effects of acute blueberry flavonoids on mood in children and young adults. Nutrients, 9(2). https://doi.org/10.3390/nu9020158
Landgraf, D., Long, J. E., y Welsh, D. K. (2016). Depression-like behaviour in mice is associated with disrupted circadian rhythms in nucleus accumbens and periaqueductal grey. European Journal of Neuroscience, 43(10), 1309–1320. https://doi.org/10.1111/ejn.13085
Li, X. L., Yuan, Y. G., Xu, H., Wu, D., Gong, W. G., Geng, L. Y., Wu, F. F., Tang, H., Xu, L., & Zhang, Z. J. (2015). Changed synaptic plasticity in neural circuits of depressive-like and escitalopram-treated rats. International Journal of Neuropsychopharmacology, 18(10), 1–12. https://doi.org/10.1093/ijnp/pyv046
Lino de Oliveira, C., Bolzan, J. A., Surget, A., & Belzung, C. (2020). Do antidepressants promote neurogenesis in adult hippocampus? A systematic review and meta-analysis on naive rodents. Pharmacology and Therapeutics, 210, 107515. https://doi.org/10.1016/j.pharmthera.2020.107515
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews Neuroscience, 10(6), 434–445. https://doi.org/10.1038/nrn2639
Martirosyan, D. M., y Singh, J. (2015). A new definition of functional food by FFC: What makes a new definition unique? Functional Foods in Health and Disease, 5(6), 209–223. https://doi.org/10.31989/ffhd.v5i6.183
National Research Council [NRC]. (2011). Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the care and use of laboratory animals, 327(3), 963-965.
NOM-062-ZOO-1999, Especificaciones técnicas para la producción, cuidado y uso de los animales de laboratorio.
O’Mahony, C. M., Sweeney, F. F., Daly, E., Dinan, T. G., & Cryan, J. F. (2010). Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour. Behavioural Brain Research, 213(2), 148–154. https://doi.org/10.1016/j.bbr.2010.04.038
Organización Mundial de la Salud [OMS]. (2021). Depresión. Recuperado 5 de junio de 2021, en https://www.who.int/es/news-room/fact-sheets/detail/depression
Paxinos, G. (2014). The rat brain in stereotaxic coordinates: Hard cover edition (6a ed.). Academic Press.
Peña-Sanhueza, D., Inostroza-Blancheteau, C., Ribera-Fonseca, A., y Reyes-Díaz, M. (2017). Anthocyanins in Berries and Their Potential Use in Human Health. En N. Shiomi, & V. Waisundara (Eds.), Superfood and Functional Food - The Development of Superfoods and Their Roles as Medicine. IntechOpen. https://doi.org/10.5772/67104
Pérez-Esparza, R. (2017). Tratamiento farmacológico de la depresión: actualidades y futuras direcciones. Revista de la Facultad de Medicina (México), 60(5), 7-16.
Pérez-Esparza, R., Kobayashi-Romero, L. F., García Mendoza, A. M., Lamas-Aguilar, R. M., Vargas Sosa, M., Encarnación-Martínez, M., González-Manríquez, L. A., Eternod-Rodríguez, S. A., Maltos-Gómez, F., Vargas-Valencia, K. M., & Fonseca Pérez-Amador, A. (2020). Ketamina, un nuevo agente terapéutico para la depresión. Revista de La Facultad de Medicina, 63(1), 6–13. https://doi.org/10.22201/fm.24484865e.2020.63.1.02
Porsolt, R. D., Le Pichon, M., y Jalfre, M. L. (1977). Depression: a new animal model sensitive to antidepressant treatments. Nature, 266(5604), 730-732.
Quick, J. C., & Henderson, D. F. (2016). Occupational stress: Preventing suffering, enhancing wellbeing. International Journal of Environmental Research and Public Health, 13(5), 1–11. https://doi.org/10.3390/ijerph13050459
Rapp, A., Dodds, A., Walkup, J. T., & Rynn, M. (2013). Treatment of pediatric anxiety disorders. Annals of the New York Academy of Sciences, 1304(1), 52–61. https://doi.org/10.1111/nyas.12318
Ravindran, L. N., & Stein, M. B. (2010). The pharmacologic treatment of anxiety disorders: a review of progress. The Journal of clinical psychiatry, 71(7).
Rivadeneyra-Domínguez, E., Vázquez-Luna, A., Rodríguez-Landa, J. F., Mérida-Portilla, C. V., & Díaz-Sobac, R. (2017). The protective effect of two commercial formats of Ginkgo biloba on motor alterations induced by cassava juice ( Manihot esculenta Crantz) in Wistar rats. Neurología (English Edition), 32(8), 516–522. https://doi.org/10.1016/j.nrleng.2016.02.010
Rivadeneyra-Domínguez, E., Vázquez-Luna, A., Rodríguez-Landa, J. F., & Díaz-Sobac, R. (2014). A standardized extract of Ginkgo biloba prevents locomotion impairment induced by cassava juice in Wistar rats. Frontiers in Pharmacology, 5(SEP), 1–6. https://doi.org/10.3389/fphar.2014.00213
Rynn, M., Puliafico, A., Heleniak, C., Rikhi, P., Ghalib, K., y Vidair, H. (2011). Advances in pharmacotherapy for pediatric anxiety disorders. Focus, 9(3), 299-310.
Snehunsu, A., Nayak, S. B., Kandwal, M., Piyali, A., Adiga, M., Sahoo, P., Medabala, T., Rao, K. R., y Joseph, A. (2019). 1-triacontanol cerotate isolated from Marsilea quadrifolia Linn. Safeguards hippocampal CA3 neurons and augments special memory deficit in chronic epileptic rats. International Journal of Morphology, 37(1), 265–272. https://doi.org/10.4067/S0717-95022019000100265
Souery, D., Papakostas, G. I., & Trivedi, M. H. (2006). Treatment-resistant depression. Journal o Clinical Psychiatry, 67, 16.
Tomić, M., Ignjatović, D. D., Tovilović-Kovačević, G., Krstić-Milošević, D., Ranković, S., Popović, T., y Glibetić, M. (2016).
Reduction of anxiety-like and depression-like behaviors in rats after one month of drinking: Aronia melanocarpa berry juice. Food and Function, 7(7), 3111–3120. https://doi.org/10.1039/c6fo00321d
UVEHAVIOR, (2020). UVEHAVIOR, link: https://github.com/Manolomon/uvehavior-desktop/releases
Valcheva-Kuzmanova, S., Eftimov, M., Denev, P., Krachanova, M., & Belcheva, A. (2013). Effect of aronia melanocarpa fruit juice on alcohol-induced depressive-like behavior in rats. Scripta Scientifica Medica, 45, 7-13.
Van Praag, H. M., de Kloet, E. R., & Van Os, J. (2004). Stress, the brain and depression. Cambridge University Press.
Vogt, B. A. (2016). Midcingulate cortex: Structure, connections, homologies, functions and diseases. Journal of Chemical Neuroanatomy, 74, 28–46. https://doi.org/10.1016/j.jchemneu.2016.01.010
Williams, R. J., Mohanakumar, K. P., y Beart, P. M. (2016). Neuro-nutraceuticals: Further insights into their promise for brain health. Neurochemistry International, 95, 1–3. https://doi.org/10.1016/j.neuint.2016.03.016
Yamamoto, T., Iwamoto, T., Kimura, S., & Nakao, S. (2018). Persistent isoflurane-induced hypotension causes hippocampal neuronal damage in a rat model of chronic cerebral hypoperfusion. Journal of Anesthesia, 32(2), 182–188. https://doi.org/10.1007/s00540-018-2458-z
Zhu, Y., Liu, F., Zou, X., & Torbey, M. (2015). Comparison of unbiased estimation of neuronal number in the rat hippocampus with different staining methods. Journal of Neuroscience Methods, 254, 73–79. https://doi.org/10.1016/j.jneumeth.2015.07.022
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2022 Katya Alexa Ramírez Lagunas, Isidro Vargas Moreno, Socorro Herrera Meza, Juan Francisco Rodríguez Landa, Abraham Puga Olguín, Rafael Fernández Demeneghi