Palabras clave
Cg1
deseperanza conductual
neuronas
zarzamora Anthocyanins
blackberry
Cg1
depression-like behavior
neurons
Cómo citar
Resumen
El estrés puede predisponer al desarrollo de trastornos psiquiátricos como la depresión. El consumo de frutos rojos ha sido asociado a un bajo riesgo padecer depresión, debido a su alto contenido de polifenoles y antocianinas. El presente estudio evaluó el efecto del jugo de zarzamora sobre la conducta tipo depresión y el número de neuronas en la región Cg1 de la corteza prefrontal de la rata. Se utilizaron 44 ratas macho Wistar divididas en 5 grupos: vehículo, zarzamora baja y alta, fluoxetina y diazepam. Los efectos se evaluaron en las pruebas de campo abierto y nado forzado. Para el análisis histológico se realizó la tinción de violeta de cresilo. El grupo tratado con la dosis alta de zarzamora produjo efectos tipo antidepresivo y un mayor número de neuronas en la región Cg1. Los resultados sugieren que el jugo de zarzamora pudiera prevenir el desarrollo de trastornos psiquiátricos asociados al estrés.
Citas
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Derechos de autor 2022 Katya Alexa Ramírez Lagunas, Isidro Vargas Moreno, Socorro Herrera Meza, Juan Francisco Rodríguez Landa, Abraham Puga Olguín, Rafael Fernández Demeneghi